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Τι (ποιος) είναι GABAA receptor - ορισμός
GABAA receptor
![PDB]]: [https://www.rcsb.org/structure/6DW1 6DW1]). Top: side view of the GABAA receptor embedded in a [[cell membrane]]. Bottom: view of the receptor from the extracellular face of the membrane. The subunits are labeled according to the GABAA nomenclature and the approximate locations of the GABA and benzodiazepine (BZ) binding sites are noted (between the α- and β-subunits and between the α- and γ-subunits respectively).](https://commons.wikimedia.org/wiki/Special:FilePath/Fig-GABAA receptor.png?width=200 "PDB]]: [https://www.rcsb.org/structure/6DW1 6DW1]). Top: side view of the GABAA receptor embedded in a [[cell membrane]]. Bottom: view of the receptor from the extracellular face of the membrane. The subunits are labeled according to the GABAA nomenclature and the approximate locations of the GABA and benzodiazepine (BZ) binding sites are noted (between the α- and β-subunits and between the α- and γ-subunits respectively).")
IONOTROPIC RECEPTOR AND LIGAND-GATED ION CHANNEL, WITH ENDOGENOUS LIGAND Γ-AMINOBUTYRIC ACID
Gaba a receptor; GABA-A receptor; Receptors, gaba-a; GABA A receptor; GABAA; Benzodiazepine receptor; BZ-sensitive GABAA receptor; GABAa receptors; Benzodiazepine receptors; Benzodiazepine site; GABAA receptors; GABA-A; GABAa receptor; Γ-Aminobutyric acid A receptor; Gaba-b receptor; Central benzodiazepine receptor; Central benzodiazepine receptors; Central Benzodiazepine Receptors; Central Benzodiazepine Receptor; Central Benzodiazepine Site; Central Benzodiazepine Sites; Central benzodiazepine sites; Benzodiazepine sites
The GABAA receptor (GABAAR) is an ionotropic receptor and ligand-gated ion channel. Its endogenous ligand is γ-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system.
GABAA-rho receptor
CLASS OF TRANSPORT PROTEINS
GABA C receptor; GABAC receptor; Γ-Aminobutyric acid A-rho receptor; Γ-Aminobutyric acid A-ρ receptor; GABAA-rho
The GABAA-rho receptor (previously known as the GABAC receptor) is a subclass of GABAA receptors composed entirely of rho (ρ) subunits. GABAA receptors including those of the ρ-subclass are ligand-gated ion channels responsible for mediating the effects of gamma-amino butyric acid (GABA), the major inhibitory neurotransmitter in the brain.
GABAA receptor positive allosteric modulator
![Fig 8. R-group position of [[Barbiturates]]](https://commons.wikimedia.org/wiki/Special:FilePath/BarbituratesR groups.jpg?width=200 "Fig 8. R-group position of [[Barbiturates]]")
![Fig 4. GABAergic synapse. The synaptic anchoring protein [[Gephyrin]] is indirectly linked to the GABAA receptors.](https://commons.wikimedia.org/wiki/Special:FilePath/GABA synapse.jpg?width=200 "Fig 4. GABAergic synapse. The synaptic anchoring protein [[Gephyrin]] is indirectly linked to the GABAA receptors.")
![Fig 7. Synthesis and discovery of [[chlordiazepoxide]]](https://commons.wikimedia.org/wiki/Special:FilePath/Synthesis and discovery of chlordiazepoxide.jpg?width=200 "Fig 7. Synthesis and discovery of [[chlordiazepoxide]]")
A SUBSTANCE THAT DOES NOT ACT AS AGONIST OR ANTAGONIST BUT DOES AFFECT THE GAMMA-AMINOBUTYRIC ACID RECEPTOR-IONOPHORE COMPLEX
GABAA receptor positive allosteric modulators; GABAA receptor PAM; GABA modulator; GABA modulators; GABAkine; GABAkines; GABAA receptor potentiator; GABAA receptor potentiators; GABAAR potentiators; GABAAR potentiator; GABA-A receptor potentiator; GABA-A receptor potentiators
In pharmacology, GABAA receptor positive allosteric modulators are positive allosteric modulator (PAM) molecules that increase the activity of the GABAA receptor protein in the vertebrate central nervous system.
